 
Below, Dr. Sharp answers a few frequently-asked questions to give consumers background information
on immune-related illnesses.
Chronic Fatigue and Immune Dysfunction Syndrome (CFIDS), also known as Chronic Fatigue Syndrome (CFS), Myalgic Encephalomyelitis
(ME), among other names, is a complex and debilitating chronic illness that affects the brain and multiple body systems. This
includes the immune, endocrine, gastrointestinal and central nervous systems.
According to the CFS case definition published in the Dec. 15, 1994 issue of the Annals of Internal Medicine, diagnosing CFIDS requires
a thorough medical history, physical and mental status examinations and laboratory tests to identify underlying or contributing
conditions that require treatment. Chronic fatigue can be classified as Chronic Fatigue and Immune Dysfunction Syndrome if the patient
meets both the following criteria:
1. Clinically evaluated, unexplained persistent or relapsing chronic fatigue that is of new or definite onset (i.e., not lifelong) is not the
result of ongoing exertion, is not substantially alleviated by rest, and results in substantial reduction in previous levels of occupational,
educational, social or personal activities.
2. The concurrent occurrence of four or more of the following symptoms: substantial impairment in short-term memory or concentration;
sore throat; tender lymph nodes; muscle pain; multi-joint pain without joint swelling or redness; headaches of a new type, pattern
or severity; unrefreshing sleep; and post-exertional malaise lasting more than 24 hours. These symptoms must have persisted or
recurred during six or more consecutive months of illness and must not have pre-dated the fatigue.
Treatment for CFIDS is intended primarily to relieve specific symptoms. One third of the patients who develop CFIDS report resolution
of symptoms over time. Another one third cycle between periods of good health and wellness and some gradually worsen. What is
required is an integrative, step-wise approach. Each patient requires an individualized protocol.
No, but patients can have both simultaneously.
The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia
To meet the diagnostic criteria, patients must have:
1. History of widespread pain for at least three months.
Definition. Pain is considered widespread when it occurs in both the right and left sides of the body, and both above and below the waist. In other
words there must be pain in all four quadrants of the body. In addition, axial skeletal pain (cervical spine or anterior chest or thoracic spine or low
back) must be present. “Low back” pain is considered lower segment pain.
2. Pain in 11 of 18 tender point sites on digital palpation.
Definition. Pain, on digital palpation, must be present in at least 11 of the following
18 sites:
Occiput: Bilateral, at the suboccipital muscle insertions.
Low cervical: bilateral, at the anterior aspects of the intertransverse spaces at
C5-C7.
Trapezius: bilateral, at the midpoint of the upper border.
Supraspinatus: bilateral, at origins, above the scapula spine near the medial
border.
Second rib: bilateral, at he second costochondral junctions, just lateral to the
junctions on upper surfaces.
Lateral epicondyle: bilateral, 2 cm distal to the epicondyles.
Gluteal: bilateral, in upper outer quadrants of buttocks in anterior fold of muscle.
Greater trochanter: bilateral, posterior to the trochanteric prominence.
Knee: bilateral, at the medial fat pad proximal to the joint line.
A diagram illustrating the location of these tender points can be seen at: http://www.nfra.net/Diagnost.htm
Digital palpation should be performed with an approximate force of 4 kg.
A tender point has to be painful at palpation, not just “tender”.
The presence of a second clinical disorder does not exclude the diagnosis of fibromyalgia.
With an integrated, step-wise approach to address:
* Gut dysbiosis/food allergies
* Sleep disorder--if the body can get adequate sleep, it may improve pain issues
* Immune dysfunction/Infections
* Endocrine disorders - thyroid, growt hormone, adrenal, sex hormone imbalances (treated with bio-identical hormones)
* Metabolic disturbances - blood volume depletion, mineral deficiency, especially magnesium, acid-base imbalance, DNA and mitochondrial damage, antioxidant depletion, mercury detoxification, brain
protection and restoration, autonomic nervous system imbalance, oxygen transport difficulty, adrenal insufficiency and pain management.
* Toxic Foci – removal of toxins from the body
 Depending on the current status of a patient in the step-wise protocol, we can carefully progress through an individualized plan of treatment. As the body begins to repair itself and heal, the next step is
implemented. This allows time to assess what is most beneficial in a partnership between physician and patient.
Why do lab results ordered by my doctor often show no abnormalities?
Routine lab tests that measure blood count, blood sugar, kidney, liver function and cholesterol are often normal in CFIDS patients. These tests are too general to find functional defects in CFIDS patients.
However, some abnormal patterns do emerge such as low sedimentation rate, low uric acid and low white cell count, as well as upregulated cholesterol levels.
There are many specialty tests I order: a few of the most commonly helpful are:
1. RNase L level - often upregulated indicating active viral infections
2. Low NK (Natural Killer) cell count and function
3. Abnormal Comprehensive Digestive Stool Analysis - indicating gut dysbiosis and/or inflammation
4. Chronic Viral Infections - HHV6, Cytomegalovirus, Mycoplasma, Chlamydia infections.
5. 24-hour urine Amino Acid analysis - can pinpoint specific vitamin, mineral and protein deficiencies.
6. Abnormal salivary melatonin level - often a CFIDS patient will not secrete melatonin at midnight, but will secrete a quantity of melatonin at 6:00AM.
This inhibits sleep, and then creates difficulty in waking.
7. Genetic screening - www.genovations.com genetic panels for detoxification and Immune dysfunction. With this information, I can pinpoint genetic
predisposition to CFIDS and direct phenotypic manipulation to shut off genes expressing inflammation, liver toxicity problems, etc.
8. Thrombotic Marker Panel or ISAC panel - (Immune System Activation of Coagulation) Hemex Labs looks for hypercoagulation problems which
1. allow pathogens to persist in the bloodstream
2. interfere with O2/CO2 transport - and thus cause fatigue and muscle pain.
9. Testing for Human Growth Hormone deficiency
10. Other hormone analysis: DHEA, Estrogen, Progesterone, Testosterone and Cortisol imbalances.
11. Saliva cortisol level – often abnormal levels are produced at incorrect times.
Please keep in mind that treatment for each patient is individualized, based on the results of a patient’s symptoms, physical exam and laboratory analysis.
Shots may be helpful; my staff carefully instructs each patient or caregiver in proper intramuscular and/or subcutaneous techniques. Some of the most
helpful injections may be:
* Magnesium + Taurine injections (Magnesium cream is also available)
* B12 (hydroxy form) (sublingual methyl tablets are also available)
* Glutathione (an oral form is also available)
* Nexavir - used to be Kutapressin (a transdermal gel is also available)
* Human Growth Hormone - very low dose
* Growth Factors – cell signaling factors
It is a powerful immune modulator that can be very helpful, although not currently available in the U.S. It can be imported utilizing a correctly written prescription. This is one of the safest, most cost effective
and helpful drugs at our disposal. Ongoing studies in Canada and Europe have proven this drug to raise NK cell count and function and correct TH1/TH2 imbalances. It is a non-specific antiviral
compound.
As a member of the IACFS, an international professional organization for clinicians and researchers who study CFIDS, I am able to follow current research in the field. I also follow the current literature on
Fibromyalgia, and there are many research projects going on that are quite hopeful.
I participated in an extensive research study completed in 2007 that was sponsored by a major pharmaceutical company to test a new drug for treating Fibromyalgia.
Of particular interest to me is the work being done on hypercoagulation issues, neurotoxins, emerging infectious agents and using nutraceuticals to balance these issues. I am most impressed with the
work of Jeffrey Bland, Ph.D., and his theories of how nutrition is related to gene expression, which in turn causes or reverses illness. I am convinced that the area Dr. Bland calls “Nutragenomics” holds
great promise for all mankind in dealing with chronic illnesses. I truly believe if we can stop polluting the world and poisoning ourselves, we may be on the verge of eradication of many illnesses.
Dr. Paul Cheney’s work on cardiac issues in CFS, based initially on the research of Peckerman, is very important and illuminating. I await with much anticipation the publication of his research on these issues.
Dr. Cheney is currently providing Cell Signaling Factors which promises to reverse some of the most disabling symptoms.
Chronic illness is often a result of genetic abnormalities and environmental toxins. There are scores of people dealing with these symptoms who can be particularly helped through detoxification techniques
developed by Dr. Cowden. We have implemented these in the clinic using laser technology and have found that effective detoxification is essential in strengthening the body’s immune system and can
speed up the healing process.
Most insurance covers some of the above. Although our office is fee-for-service at the time of your appointment, we will give you the information you need to file with your insurance company for reimbursement
according to your out-of-network benefits. There may be additional costs for lab tests or procedures done outside the clinic. The cost of an initial visit is influenced by various factors such as the
complexity of the illness and evaluation of disability issues.
NEVER GIVE UP HOPE! I know that is easier said than done, but there is hope and there is help available for you to regain control of your life. Research is moving forward and as these conditions gain
more national attention, more research will be funded to develop even more treatment options for patients.
Keep reading and educating yourself and your health care provider on the options available that have proven medical outcomes. Often physicians who do not specialize in this area of medicine, but are
working hard to help their patients with FM/CFIDS, welcome information regarding these treatment options since they don’t have time to stay on top of the latest options that are helping other patients. The
Internet has a wealth of information on it and resources for patients and health care professionals alike.
Next, know you are not alone. Right now it is estimated that here are over 12 million Americans suffering from these debilitating conditions and their stories of pain, exhaustion and loss of quality in their
lives are similar. So while each patient has a unique presentation of these conditions, each experiences similar struggles.
And finally, keep searching for health care providers who “get it”. If you are being treated by a physician who does not recognize that this is a very real condition, find a new health care provider. And, if you
are being treated by a provider and are not seeing a significant improvement within 6-12 months, or if your practitioner is not open to trying other treatments, find a new provider. If you suffer from depression,
know that most likely you are not sick because you are depressed; you are depressed because you are sick.
These are very real conditions that can and will rob you of your life if you don’t get them under control. It is important that you take control of your health care choices and the path you follow as you work to
overcome these overpowering diseases.
The Marshall Protocol (MP) is a treatment developed in 2002 by Trevor Marshall for diseases having a Th1
type immune response. Patients with autoimmune illness CFS, FM, Lyme and Sorcoidosis have been successfully
treated with this protocol. It works by allowing the immune system to destroy intracellular bacteria that are
thought to be the root cause of the illness.
When L-form bacteria (cell wall deficient forms) are detected, part of the immune system called Th-1 lymphocytes
become activated. These white blood cells (WBC’s) produce cytokines which are chemicals that are proinflammatory
causing other WBC’s such as B-lymphocytes and neutrophils to become more active. The purpose
is to enhance overall immune function but can lead to overactive, autoimmune conditions. When the immune
system becomes overactivated, people have a hard time keeping other pathogens under control. This may trigger
reactivation of childhood viral infections such as the Epstein-Barr Virus (cause of mononucleosis).
The other problem related to Th-1 diseases is the increased production of a Vitamin-D metabolite called 125 Dihydroxy
Vitamin-D. Avoiding Vitamin-D is the first step in implementing the MP. This has long been documented
in Sorcoidosis as it has been reported that Vitamin-D worsens Sorcoidosis.
Next, the drug, Benecar, is utilized to suppress inflammation and to activate the immune system as well as correct
the Vitamin-D abnormality. Finally, low dose antibiotics are prescribed to remove the intracellular bacteria
not killed by the immune system. We test every new patient for Vitamin-D problems.
For more information see: www.marshallprotocol.com • www.chronicillnessrecovery.org
According to Paul Cheney, MD, PhD., these treatments can be very helpful. Cell signaling factors (CSF) also know as Growth Factors or Live Cell Therapy has been available since the 1930’s. These
are extracts from healthy tissue, organs and glands which, according to Paul Cheney, reset the phenotype of the person being treated. Dr. Cheney compares this to reprogramming a computer. When a
person survives a serious illness, the body has made certain adaptive changes. Some genes are now up-regulated while others are down-regulated. This gene rearrangement may allow you to survive,
but not necessarily feel well. By using these factors, Dr. Cheney believes one can re-boot the body back to the original starting point.
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Is CFIDS the same thing as Fibromyalgia?
What is Fibromyalgia?
What advice do you have for CFS and FM patients?